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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC4
All Species:
23.64
Human Site:
Y225
Identified Species:
52
UniProt:
P56524
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56524
NP_006028.2
1084
119040
Y225
Q
S
G
V
S
T
S
Y
N
H
P
V
L
G
M
Chimpanzee
Pan troglodytes
XP_001151115
1072
118186
Y199
L
S
G
T
S
P
S
Y
K
Y
T
L
P
G
A
Rhesus Macaque
Macaca mulatta
XP_001099472
1009
112349
R163
V
E
L
L
N
P
A
R
V
N
H
M
P
S
T
Dog
Lupus familis
XP_849514
1222
133391
Y319
Q
S
G
V
S
A
S
Y
N
H
P
V
L
G
M
Cat
Felis silvestris
Mouse
Mus musculus
Q6NZM9
1076
118544
Y224
Q
S
G
V
S
A
S
Y
N
H
P
V
L
G
M
Rat
Rattus norvegicus
Q99P99
1077
118634
Y224
Q
S
G
V
S
A
S
Y
N
H
P
V
L
G
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510939
1082
119892
Y228
Q
S
G
V
S
A
T
Y
N
H
P
V
L
G
M
Chicken
Gallus gallus
P83038
1080
119449
Y224
Q
S
G
V
S
G
T
Y
N
H
P
V
L
G
M
Frog
Xenopus laevis
Q9YGY4
596
67288
Zebra Danio
Brachydanio rerio
Q6PBI4
582
65098
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17323
816
88964
N57
Q
H
S
T
E
D
Q
N
S
G
P
A
A
P
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.7
76.5
79.6
N.A.
93.6
93.4
N.A.
90.8
90.6
27.3
26.3
N.A.
N.A.
N.A.
32.2
N.A.
Protein Similarity:
100
73.9
77.9
82.9
N.A.
96.3
96.1
N.A.
94.9
95
38.1
37.5
N.A.
N.A.
N.A.
46.4
N.A.
P-Site Identity:
100
40
0
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
0
0
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
53.3
33.3
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
0
0
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
37
10
0
0
0
0
10
10
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
64
0
0
10
0
0
0
10
0
0
0
64
0
% G
% His:
0
10
0
0
0
0
0
0
0
55
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
10
0
10
10
0
0
0
0
0
0
0
10
55
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
55
% M
% Asn:
0
0
0
0
10
0
0
10
55
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
19
0
0
0
0
64
0
19
10
0
% P
% Gln:
64
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
0
64
10
0
64
0
46
0
10
0
0
0
0
10
0
% S
% Thr:
0
0
0
19
0
10
19
0
0
0
10
0
0
0
10
% T
% Val:
10
0
0
55
0
0
0
0
10
0
0
55
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _